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Synthesis 2001; 2001(1): 0046-0048
DOI: 10.1055/s-2001-9755
short paper
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A Short and Efficient Synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic Acid

R. Stürmer* , B. Schäfer, V. Wolfart, H. Stahr, U. Kazmaier, G. Helmchen
  • *BASF AG, Hauptlaboratorium, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany; Fax +49(621)6 04 22 90; E-mail: bernd2.schaefer@knoll-ag.de
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Publication Date:
31 December 2001 (online)

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A short and efficient synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid is described. Starting from N-Boc-diallylamine, the synthesis involves ring-closing metathesis (RCM), directed alkoxycarbonylation (using strong lithium bases and alkyl carbonates) and enzymatic kinetic resolution of the racemate.

alkoxycarbonylation - enzymes - lithiation - metathesis - kinetic resolution

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