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Synlett 2001; 2001(12): 1992-1994
DOI: 10.1055/s-2001-18766
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Aldolases as Leitmotiv - A Nonenzymatic Domino Aldol Reaction Triggered by Zinc Bisenolate and Polyenolate (ate) Complexes

Michael Schmittel* , Manas K. Ghorai
  • *FB 8 (Chemie - Biologie), Organische Chemie I, Universität Siegen, Adolf Reichwein Str., 57068 Siegen, Germany; Fax: + 49(271)7403270; E-mail: schmittel@chemie.uni-siegen.de
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Publication Date:
04 December 2001 (online)

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A new zinc(II) mediated sequential aldol reaction is described for the diastereoselective one-pot synthesis of tetrahydropyran-2,4-diols. The dependence of the yield on the ratio Zn2 +/enolate proposes that zinc(II) polyenolate and ate complexes may be involved.

aldol reactions - domino reactions - zinc - stereoselective synthesis - hemiacetal

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