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Synlett 2001; 2001(7): 1185-1187
DOI: 10.1055/s-2001-15167
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Advantage of Anaerobic Conditions in the Highly Enantioselective Synthesis of α,α-Dialkyl-α-Amino Acids by Chiral Phase-Transfer Catalysis

Takashi Ooi* , Mifune Takeuchi, Daisuke Ohara, Keiji Maruoka
  • *Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan; Fax + 81-75-753-40 41; E-mail: maruoka@kuchem.kyoto-u.ac.jp
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Publication Date:
31 December 2001 (online)

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Intervention of the enolate oxidation in the catalytic asymmetric phase-transfer alkylation of protected α-amino acid derivatives under aerobic conditions has been addressed, and anaerobic conditions have been introduced to obtain synthetically satisfactory chemical yields as well as a high level of enantioselectivity.

alkylation - anaerobic conditions - chiral phase-transfer catalysis - protected α-amino acid derivatives - oxidation

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