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Synlett 2000; 2000(6): 0862-0864
DOI: 10.1055/s-2000-6731
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An Efficient Synthesis of (2S)-2-[4-((1R,2S)-2-Hydroxycyclopentylmethyl)phenyl]propionic Acid

Tadakatsu Mandai* , Tomio Yamakawa
  • *Department of Chemical Technology, Kurashiki University of Science & the Arts, 2640 Nishinoura, Tsurajima-cho, Kurashiki 712-8505, Japan; Fax +81-86-440-1062; E-mail: ted@chem.kusa.ac.jp
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Publication Date:
31 December 2000 (online)

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An efficient synthesis of (2S)-2-[4-((1R,2S)-2-hydroxycyclopentylmethyl)phenyl}propionic acid via lipase-catalyzed kinetic resolution of (-)-N-[(1S)-1-phenylethyl]-(±)-2-[4-(trans-2-hydroxycyclopentylmethyl)phenyl] propionamide is successfully accomplished.

anti-inflammatory agent - 2-arylpropionic acid derivative - lipase - asymmetric acetylation - kinetic resolution

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