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Synlett 2000; 2000(6): 0838-0840
DOI: 10.1055/s-2000-6729
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Palladium-Catalyzed Carbonylation of Lactone-Derived Enol Phosphates: Stereoselective Construction of Functionalized Cyclic Ethers from Lactones

Makoto Sasaki* , Shugo Honda, Tetsuji Noguchi, Hiroyuki Takakura, Kazuo Tachibana
  • *Department of Chemistry, Graduate School of Science, The University of Tokyo, and CREST, Japan Science and Technology Corporation (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Fax +81-3-5841-8380; E-mail: msasaki@chem.s.u-tokyo.ac.jp
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Publication Date:
31 December 2000 (online)

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A strategy for the functionalization of lactones to afford cyclic ethers has been developed. The present synthesis involves palladium(0)-catalyzed carbonylation of lactone-derived enol phosphates and stereoselective hydroboration.

cyclic ether - carbonylations - enol phosphate - lactones - palladium

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