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Synthesis 2000; 2000(4): 557-560
DOI: 10.1055/s-2000-6376
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A Versatile Approach to Anti-Asthmatic Compound CMI-977 and its Six-Membered Analogue

Mukund K. Gurjar* , L. Murali Krishna, B. Sridhar Reddy, Mukund S. Chorghade
  • *National Chemical Laboratory, Pune 411008, India
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Publication Date:
31 December 2000 (online)

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The synthesis of the anti-asthmatic compound CMI-977 is described. The tetrahydrofuran ring was effectively constructed by involving olefin metathesis while the stereoselective introduction of the 1-N-hydroxyureidylbut-3-yn-4-yl side-chain was achieved by C-alkylation of the 2-benzenesulfonyl derivative.

anti-asthmatic - olefin metathesis - stereoselective synthesis - tetrahydrofuran - tetrahydropyran - nucleophilic displacement

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