Download PDF
Synthesis 2000; 2000(2): 220-222
DOI: 10.1055/s-2000-6259
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Diastereoselective Synthesis of Protected 2,3-Dihydroxynitriles from 2-Hydroxy Acids

Pierre Hutin* , Marc Larchevêque
  • *Laboratoire de Synthèse Organique, UMR 7573 du CNRS, ENSCP, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France; Fax +33 (1) 43 25 79 75; E-mail: larchm@ext.jussieu.fr
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The DIBAL-H reduction of dioxolanones 2 prepared from 2-hydroxy acids followed by addition of acetone cyanohydrin affords the syn 2,3-dihydroxynitriles in high enantiomerical purities.

Grignard compounds - nitrile - diastereoselective reduction

      >