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Synthesis 1999; 1999(4): 580-582
DOI: 10.1055/s-1999-3439
short paper
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Synthesis of Hyrtiosin B, a Bis-indole Alkaloid from the Okinawan Marine Sponge Hyrtios erecta

Jan Bergman* , Tomasz Janosik, Ann-Louise Johnsson
  • *Department of Organic Chemistry, KI, Novum Research Park, SE-14157 Huddinge, Sweden; Fax +46(8)6 08 15 01; E-mail: jabe@cnt.ki.se
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Publication Date:
31 December 1999 (online)

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The bis-indole alkaloid hyrtiosin B (1) has been prepared in good yield from 5-benzyloxyindole (4a) or 5-methoxyindole (4b), involving a coupling reaction of the zinc metallated indoles with the corresponding glyoxylyl chlorides 5a-b, and finally debenzylation or demethylation using boron tribromide to yield the title compound 1.

hyrtiosin B - bis-indole alkaloids - transmetallation - O-dealkylation

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