Download PDF
Synlett 1999; 1999(5): 571-572
DOI: 10.1055/s-1999-2690
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Construction of the Diene Moiety (C9-C18) of Amphidinolide B, a 26-Membered Macrolide

Katsuhide Ohi* , Shigeru Nishiyama
  • *Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Yokohama 233-8522, Japan; Fax +81-45-5 63-59 67; E-mail: nisiyama@chem.keio.ac.jp
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

The diene moiety (C9-C18) of amphidinolide B, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been synthesized by a coupling reaction of an alkynyl anion of 5 and the aldehyde 7, followed by Michael addition and methylenation.

marine natural products - Amphidinolide B - cytotoxic activity

      >