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Synlett 1998; 1998(10): 1162-1164
DOI: 10.1055/s-1998-1858
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Enantioselective Hydrogenation of Functionalized Ketones. Synthesis and Application of New Chiral Aminophosphine-Phosphinite Ligands

Corinne Pasquier* , Jürgen Eilers, Iris Reiners, Jürgen Martens, André Mortreux, Francine Agbossou
  • *Laboratoire de Catalyse Hétérogène et Homogène, URA CNRS 402, Groupe de Chimie Appliquée de l'ENSC Lille, Université des Sciences et Technologies de Lille, BP 108 - 59652 Villeneuve d'Ascq Cedex, France; Fax 33 3 20 43 65 85; E-mail: agbossou@ensc-lille.fr
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Publication Date:
31 December 2000 (online)

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The chiral new aminophosphine-phosphinites (AMPP's 1-7) have been synthesized and applied successfully in the enantioselective hydrogenation of dihydro-4,4-dimethyl-2,3-furandione 8, N-benzylbenzoylformamide 9, and ethylpyruvate 10 providing the hydroxy products in up to 97, 95, and 80% ee, respectively.

asymmetric hydrogenation - aminophosphine-phosphinite - ketones - rhodium(I) - ruthenium(II)

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