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Synlett 1997; 1997(2): 214-216
DOI: 10.1055/s-1997-746
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Palladium Catalysed Cross-Coupling Reaction with Indolylborate: A Concise Access to Ellipticine Derivatives

Minoru Ishikura1 , Toshikatsu Yaginuma2 , Isao Agata1 , Yoshihisa Miwa3 , Reiko Yanada3 , Tooru Taga3
  • 1Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-02, Japan, Fax (0)1332 3 1245
  • 2Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-02, Japan
  • 3Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-01, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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A novel approach to ellipticine derivatives is described. The palladium catalysed cross-coupling reaction of indolylborate 1 with vinylbromides 4 gives hexatrienes 5, which are subsequently converted to pyrido[4,3-b]carbazoles. In addition, the acid promoted spiroannelation reaction of hexatrienes 5 is observed to give spiroindoles 9.

indolylborate - cross-coupling reaction - pyridocarbazole - 2-spiroindole

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