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Synlett 1996; 1996(7): 687-689
DOI: 10.1055/s-1996-5570
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Conformationally Constrained DNA Mimics: Synthesis of a Novel Cyclopropyl-Amide Linked Dimer

Becky Haly, Ramesh Bharadwaj, Yogesh S. Sanghvi*
  • *Medicinal Chemistry Department, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA 92008, U.S.A., Phone: 619-603 2351, Fax: 619-929 0036, e-mail: ysanghvi@isisph.com
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Publication History

Publication Date:
31 December 2000 (online)

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Synthesis of a new conformationally constrained dimeric building-block containing a cyclopropyl-amide functionality is described. Potential application of this dimer for antisense oligonucleotides is discussed.

Antisense - Cyclopropyl nucleoside - Michael reaction - Amide backbone - Sugar-backbone conformation

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