Synlett 1996; 1996(3): 275-277
DOI: 10.1055/s-1996-5375
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Nucleophilic Opening of Epoxide by Guanidine. A Route to Potential Substrates or Inhibitors of NO Synthases1

Christine Gravier-Pelletier, Didier Bourissou, Yves Le Merrer* , Jean-Claude Depezay
  • *Université René Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, associé au CNRS, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France
Further Information

Publication History

Publication Date:
31 December 2000 (online)

An efficient method for the synthesis of monosubstituted guanidines has been developed through the regiospecific nucleophilic opening of an epoxide by free guanidine followed by in situ selective N,N’-bis-benzyloxycarbonyl protection of the guanidine moiety.