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Synlett 1996; 1996(2): 167-168
DOI: 10.1055/s-1996-5344
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Synthesis of 4-Borono-L-phenylalanine

Christophe Malan, Christophe Morin*
  • *Laboratoire d’Etudes Dynamiques et Structurales de la Sélectivité, Bâtiment Chimie Recherches, Université de Grenoble, B.P. 53X, 38041 Grenoble (France)
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Publication Date:
31 December 2000 (online)

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An enantiospecific synthesis of 4-borono-L-phenylalanine (L-BPA) is presented. Using a new boronic acid protecting group, palladium-catalysed coupling of a protected iodo-phenylboronic derivative with a L-serine-derived partner forms the basis of this approach.

Borophenylalanine - organozinc - palladium cross-coupling - boroneutrotherapy

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