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Synthesis 1996; 1996(11): 1286-1288
DOI: 10.1055/s-1996-4399
short paper
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Activation of Imidazolides Using Methyl Trifluoromethanesulfonate: A Convenient Method for the Preparation of Hindered Esters and Amides

Gerardo Ulibarri, Nadège Choret, Dennis C. H. Bigg*
  • *Institut Henri Beaufour, 17 avenue Descartes, F-92350 Le Plessis-Robinson, France
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Publication History

Publication Date:
31 December 2000 (online)

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Treatment of imidazolides with methyl trifluoromethanesulfonate followed by reaction with alcohols or amines provides a convenient one-pot procedure for the preparation of esters and amides. The method is applicable to imidazolides of low reactivity as well as to hindered nucleophiles.

esters - amides - 1,1’-carbonyldiimidazole - imidazolides - methyl trifluoromethanesulfonate

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