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Synthesis 1996; 1996(5): 591-593
DOI: 10.1055/s-1996-4262
short paper
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Halogenated Analogs of the Antimalarial Bialamicol

Manfred Schlosser* , Dominique Michel, Simon L. Croft
  • *Institut de Chimie Organique de l’Université, Bâtiment de Chimie (BCh), CH-1015 Lausanne-Dorigny, Switzerland
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Publication Date:
31 December 2000 (online)

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In a successful attempt to amplify the pharmacological activity of the antimalarial bialamicol, substituents have been introduced in the 2-position of the allyl side chains. 2-Fluoroallyl bromide, a versatile C3F building block, is described for the first time.

C3F building block - 2-fluoroallyl moieties - Claisen rearrangement - Mannich reaction - tropical diseases

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