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Synlett 1993; 1993(5): 349-350
DOI: 10.1055/s-1993-22451
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Aza-Cope/Mannich Tandem Reaction Applied to the Asymmetric Synthesis of a Homochiral Proline Derivative

Claude Agami* , François Couty, Jing Lin, Axelle Mikaeloff
  • *Université Pierre et Marie Curie, Laboratoire de Chimie Organique, URA 408, Tour 45, 4, place Jussieu, F-75005 Paris, France
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Publication Date:
19 March 2002 (online)

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The synthesis of a homochiral 4-substituted proline derivative was achieved via a reaction sequence whose key-step was a cationic aza-Cope rearrangement/Mannich cyclization. This tandem reaction allowed a stereoselective creation of two stereogenic centers.

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