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Synthesis 1992; 1992(8): 753-755
DOI: 10.1055/s-1992-26217
short paper
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The Synthesis of 2,3-Ring-Fused Analogues of 7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone

Ronald K. Russell* , Caroline E. van Nievelt, Richard A. Rampulla, Dieter H. Klaubert, Stanley C. Bell
  • *The R. W. Johnson Pharmaceutical Research Institute, Division of Medicinal Chemistry, P. O. Box 300, Route 202, Raritan, New Jersey, 08869-0602 USA
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Publication Date:
17 September 2002 (online)

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The lithium enolate of cyclic ß-oxo sulfides has been shown to react with selected isatoic anhydrides to afford novel 9-oxothieno-,10-oxothiopyrano- and 11-oxothiepino[3,2-b]quinolines. These cyclic sulfide compounds were then oxidized with 3-chloroperoxybenzoic acid to afford either the corresponding 1-oxides or 1,1-dioxides.

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