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Synlett 1990; 1990(6): 331-332
DOI: 10.1055/s-1990-21081
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Total Synthesis of Avermectin B1a: Synthesis of the Carbohydrate Bis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone

Mark J. Ford* , Julian G. Knight, Steven V. Ley, Sadie Vile
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, London, SW7 2AY, England
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Publication Date:
08 March 2002 (online)

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A synthesis of the bis-oleandrose fragment of avermectin B1a (1) is described, involving π-allyl tricarbonyliron lactone complexes as key synthetic intermediates. Final glycosidation to the aglycone employed the use of an imidazolylthiocarbonyl glycoside, to conclude the total synthesis of avermectin B1a.

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