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Synthesis 1989; 1989(7): 497-500
DOI: 10.1055/s-1989-27299
DOI: 10.1055/s-1989-27299
paper
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Nucleotides XXIX.1 Solution Synthesis of Protected Di-2′-deoxynucleoside Phosphotriesters and Thiophosphotriesters via the Phosphoramidite Approach
Further Information
Publication History
Publication Date:
17 September 2002 (online)
The synthesis of the fully protected 16 possible natural di-2′-deoxynucleoside phosphotriesters 6aa-dd and 16 thiophosphotriesters 7aa-dd was achieved by the phosphoramidite approach in solution in preparative scale. The 5′-O-dimethoxytrityl-2′-deoxyribonucleoside 3′-[2-(p-nitrophenyl)ethyl] phosphoromorpholidites 3a-d and the 3′-O-benzyl-2′-deoxyribonucleosides 4a-d were used as starting materials.