Download PDF
Synthesis 1988; 1988(5): 401-402
DOI: 10.1055/s-1988-27592
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Facile Synthesis of (S)-Isoserine from (S)-Malic Acid

Hiroshi Maeda* , Mamoru Suzuki, Hiroshi Sugano, Kazuo Matsumoto
  • *Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., 16-89 Kashima-3-chome, Yodogawa-ku, Osaka 532, Japan
Further Information

Publication History

Publication Date:
20 August 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Reaction of (S)-malic acid 1-monobenzyl ester with diphenoxyphosphoryl azide in the presence of triethylamine gives benzyl (S)-2-oxooxazolidine-5-carboxylate, which is readily converted into (S)isoserine by alkaline hydrolysis.

      >