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Synthesis 1987; 1987(5): 471-474
DOI: 10.1055/s-1987-27973
DOI: 10.1055/s-1987-27973
paper
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A Novel Synthesis of Bicyclic Isoxazolines via Sequential Michael and Intramolecular 1,3-Dipolar Additions
Further Information
Publication History
Publication Date:
18 September 2002 (online)
Bicyclic isoxazolines are obtained in good yields by the titanium tetrachloride-mediated reaction of allylic stannanes with 1-nitroalkadienes. Titanium tetrachloride converts stannyl nitronates generated in the Michael addition step to nitrile oxide equivalents which, on adding triethylamine, undergo intramolecular 1,3-dipolar cycloaddition to give the isoxazolines.