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Synthesis 1986; 1986(10): 862-864
DOI: 10.1055/s-1986-31809
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Pyridazines; XXX1,2 . A Novel Approach to Pyrido[2,3-d] pyridazines by Annelation of the Pyridine Ring to the 1,2-Diazine System

N. Haider* , G. Heinisch
  • *Institute of Pharmaceutical Chemistry, University of Vienna, Währingerstraße 10, A-1090 Vienna, Austria
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Publication Date:
20 August 2002 (online)

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Procedures for high-yield syntheses of 2-ethoxy- and 2-dimethylamino-4-arylpyrido [2,3-d]pyridazines (3a, b, 5), 3-alkyl- and 1-alkyl-4-aryl-1,2-dihydro-2-oxopyrido[2,3-d]pyridazines (4b, 6) as well as ethyl 4-aryl-1,2-dihydro-2-oxopyrido[2,3-d]pyridazine-3-carboxylates (7a, b) starting from 5-amino-4-pyridazinyl aryl ketones (1a, b) are reported. Considerable variability of the substitution pattern in the pyridine moiety of this bicyclic system is provided by the proposed strategy of annelation of the pyridine ring to a preformed pyridazine nucleus.

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