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Synthesis 2021; 53(06): 1157-1162
DOI: 10.1055/s-0040-1706482
DOI: 10.1055/s-0040-1706482
paper
Direct and Regioselective C(sp3)–H Bond Fluorination of 2-Alkylazaarenes with Selectfluor
This work was supported by the Centre National de la Recherche Scientifique (CNRS) and Université de Lille (PEPS 174920).
Abstract
Herein, a regioselective and direct monofluorination strategy of pyridylic and quinolinic C(sp3)–H bonds was developed under transition-metal-free conditions with Selectfluor. The reaction was performed under smooth conditions and afforded fluorinated azaheterocycles including 2-methylpyridines and -quinolines in moderate to good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706482.
- Supporting Information
Publication History
Received: 10 July 2020
Accepted after revision: 02 September 2020
Article published online:
07 October 2020
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For selective examples see: