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Synlett 2018; 29(08): 1122-1124
DOI: 10.1055/s-0036-1591542
DOI: 10.1055/s-0036-1591542
letter
Copper(II)-Promoted Mono-Selective ortho C–H Chlorination of Arenes by Using Trimethyl(trichloromethyl)silane
National Natural Science Foundation of China (21662024). Natural Science Foundation of Gansu Province (1606RJZA028). Young Scholars Science Foundation of Lanzhou Jiaotong University (2016008).Further Information
Publication History
Received: 08 December 2017
Accepted after revision: 17 January 2018
Publication Date:
15 February 2018 (online)
Abstract
The first example of a Cu-promoted ortho-chlorination of aryl C–H bonds by using TMSCCl3 as chlorinating agent is reported. This reaction features a high selectivity toward monochlorination over dichlorination, compatibility with a variety of functional groups, and gram-scale synthesis.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591542.
- Supporting Information
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For selected examples of N-heteroarenes directed, palladium-catalyzed, direct chlorination of C(sp2)–H bonds, see: