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Synthesis 2016; 48(22): 3957-3964
DOI: 10.1055/s-0035-1562461
DOI: 10.1055/s-0035-1562461
paper
Synthesis of Tröger’s Base Analogues via a Phase-Transfer-Catalyzed Double Aza-Michael Reaction under Base-Free Conditions
Further Information
Publication History
Received: 18 April 2016
Accepted after revision: 06 June 2016
Publication Date:
19 July 2016 (online)
Abstract
The potential of phase-transfer catalysis in the synthesis of Tröger’s base analogues via a double aza-Michael addition has been evaluated. It has been observed that no external base is required and PTC may significantly enhance the efficiency of the process or control the selectivity.
Key words
Tröger’s base - double aza-Michael addition - phase-transfer catalysis - base-free - organic synthesisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-15602461.
- Supporting Information
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