Synthesis 2016; 48(05): 710-722
DOI: 10.1055/s-0035-1561288
paper
© Georg Thieme Verlag Stuttgart · New York

Regio- and Stereoselective Synthesis of Benzo-δ-sultams by Palladium­-Catalyzed Hydrocarbonation of Alkynes

Sudarshan Debnath
Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India   eMail: shovan.mondal@visva-bharati.ac.in   eMail: shovanku@gmail.com
,
Shovan Mondal*
Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India   eMail: shovan.mondal@visva-bharati.ac.in   eMail: shovanku@gmail.com
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Publikationsverlauf

Received: 02. Oktober 2015

Accepted after revision: 20. November 2015

Publikationsdatum:
04. Januar 2016 (online)


Abstract

An efficient method for the synthesis of benzo-δ-sultams [(4Z)-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosultams in excellent yields under mild conditions. The stereochemistry of the exocyclic double bond of the benzosultam derivatives is confirmed by single-crystal X-ray diffraction.

Supporting Information

 
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