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Synthesis 2011(12): 1831-1839  
DOI: 10.1055/s-0030-1260049
FEATUREARTICLE
© Georg Thieme Verlag Stuttgart ˙ New York

A Novel Catalyst-Free Tandem Reaction for the Synthesis of 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones in Water Medium

Ming-Yu Wu, Kun Li*, Na Wang, Ting He, Xiao-Qi Yu*
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. of China
Fax: +86(28)85415886; e-Mail: xqyu@tfol.com;
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Publication History

Received 30 December 2010
Publication Date:
26 May 2011 (online)

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Abstract

A novel catalyst-free, water-medium, tandem reaction for the synthesis of 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was developed through a one-pot strategy from nitroethylenes and 1,3-dicarbonyl compounds. A series of 1-aryl-2-nitroethenes and 1-nitroalk-1-enes were surveyed to determine the scope of this tandem reaction with moderate to good yield.

Key words

5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones - catalyst-free - water medium - tandem reaction

    Primary data for this article are available online and can be cited using the following DOI: 10.4125/pd0012th:
  • Primary Data

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CCDC 800819 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge crystallographic Data Centre via www.ccdc.cam.ac.uk/data _request/cif.