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Synthesis 2010(3): 425-430  
DOI: 10.1055/s-0029-1217142
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Stereoselective Synthesis of Novel Isonucleoside Analogues of Purine with a Tetrahydropyran Ring

Laura Estévez, Pedro Besada, Yagamare Fall, Marta Teijeira, Carmen Terán*
Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, 36310 Vigo, Spain
Fax: +34(986)812262; e-Mail: mcteran@uvigo.es;
Further Information

Publication History

Received 24 July 2009
Publication Date:
24 November 2009 (online)

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Abstract

New tetrahydropyran isonucleoside derivatives of purine, with cis or trans configuration, were stereoselectively synthesized in moderate yield by a convergent strategy based on Mitsunobu coupling. The key starting material was a bicyclic lactone.

Key words

isonucleosides - heterocycles - tetrahydropyran - purine - Mitsunobu reaction

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