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Synthesis
DOI: 10.1055/a-2802-6100
DOI: 10.1055/a-2802-6100
Short Review
Published as part of the Special Topic 22nd International Symposium on Organometallic
Chemistry Directed Towards Organic Synthesis (OMCOS-22)
1,n-Metal Migrations Mediated by 3d Transition Metals
Authors
Funding Information Support has been provided in part by JSPS KAKENHI Grant Numbers JP25K01767 (Grant-in-Aid for Scientific Research (B), R.S.); JP24H01856 (Grant-in-Aid for Transformative Research Areas (A) Green Catalysis Science, R.S.); JP25K18035 (Grant-in-Aid for Early-Career Scientists, I.F.).
Dedicated
Dedicated to the successful OMCOS-22 International Symposium on Organometallic Chemistry Directed Toward Organic Synthesis.
Abstract
Remote functionalization of unactivated sites remains a major challenge in transition-metal-catalyzed synthesis. This short review summarizes recent advances in through-space 1,n-metal migration reactions mediated by 3d transition metals, including Cr, Fe, Co, Ni, and Cu. These transformations enable site-selective bond formation at otherwise inaccessible positions and offer sustainable alternatives to conventional cross-coupling strategies. Mechanistic aspects such as ligand-controlled migration, σ-bond metathesis, isotope-labeling studies, and computational insights are highlighted to illustrate how regio- and stereoselectivity are achieved. Collectively, 3d metal-mediated 1,n-migration reactions provide a versatile platform for remote functionalization and open new avenues for reaction design in modern organic synthesis.
Keywords
Metal migration - 3d transition metals - Remote C–H activation - Organometallic chemistry - C–Si activation - C–B activationPublication History
Received: 16 January 2026
Accepted after revision: 02 February 2026
Accepted Manuscript online:
02 February 2026
Article published online:
11 February 2026
© 2026. Thieme. All rights reserved.
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