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Synlett
DOI: 10.1055/a-2778-8313
Letter

The Synthesis of Amides by Photoexcited o-Nitrophenyl Benzyl Ethers and Evaluation of Biological Activity

Authors

  • Xinran Zhang

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Yan Wei

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Huilin Ling

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Qikun Yin

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Xianhe Fang

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

Supported by: Scientific Research Foundation for Doctor of Yantai University YX22B87
Supported by: Science and Technology Support Program for Youth Innovation in Universities of Shandong Province 2023KJ367
Supported by: Natural Science Foundation of Shandong Province ZR2023QB012
Supported by: National Natural Science Foundation of China 22301261
Further Information
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Herein, we developed a method for the synthesis of amides, novel photoproducts obtained from photoexcited o-nitrophenyl benzyl ethers in metal free conditions. Furthermore, evaluation of the biological activity revealed that compound 2s exhibits inhibitory effect on LPSinduced NO release in RAW 264.7 cells.



Publication History

Received: 03 December 2025

Accepted after revision: 23 December 2025

Accepted Manuscript online:
24 December 2025

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