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DOI: 10.1055/a-2759-6541
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Metal Catalysis within Tyrosine Bioconjugation

Autoren

  • Carlota Girón-Elola

    1   UPV/EHU, Universidad del Pais Vasco - Campus de Gipuzkoa, San Sebastián, Spain (Ringgold ID: RIN83067)

  • Arkaitz Correa 

    2   Organic Chemistry I, Universidad del Pais Vasco, Donostia, Spain (Ringgold ID: RIN16402)

Gefördert durch: Ministerio de Ciencia e Innovación PID2021-122889NB-I00
Gefördert durch: Ministerio de Universidades FPU22/00522
Gefördert durch: Eusko Jaurlaritza IT1741-22
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The post-modification of biomolecules in a late-stage fashion constitutes an unmet challenge of paramount importance within organic chemistry, drug discovery and chemical biology. The functionalization of otherwise unreactive C-H bonds holds great promise for reducing the reliance on existing functional groups, thereby streamlining the chemical syntheses. Despite the extensive repertoire of peptide labelling techniques currently available, the site-selective modification of tyrosine (Tyr) compounds remains comparatively underexplored. This review highlights the state-of-the-art regarding the use of metal catalysis within the ortho-C-H functionalization of Tyr-containing compounds.



Publikationsverlauf

Eingereicht: 03. Oktober 2025

Angenommen nach Revision: 29. November 2025

Accepted Manuscript online:
29. November 2025

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