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DOI: 10.1055/a-2704-6331
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The Application of Alkynes as 1,2-dicarbonyl Substitutes in Organic Synthesis Through Iodination and Kornblum Oxidation

Swadhin Swaraj Acharya
1   Organic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Brahmapur, India (Ringgold ID: RIN74974)
,
Padma Ranjan Rout
1   Organic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Brahmapur, India (Ringgold ID: RIN74974)
,
Bibhuti Bhusan Parida
2   Organic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Berhampur, India (Ringgold ID: RIN74974)
› Author Affiliations
Supported by: OSHEC, Govt. of Odisha 293/249/OSHEC
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The 1,2-dicarbonyls are excellent moieties in organic synthesis and they offer scope for the synthesis of numerous interesting heterocycles. Likewise, the alkynes are widespread in nature and drugs. Herein, the present article highlights the application of alkynes in organic synthesis as 1,2-dicarbonyl surrogates by I2/DMSO and NIS/DMSO mediated oxidations through a cascade of iodination and Kornblum oxidation. These approaches are mild, efficient, and tolerate many functional groups. The NIS/DMSO, and iodine-DMSO mediated oxidation of alkynes to 1,2-dicarbonyl compounds and trapping by several nucleophiles to construct important diversely functionalized heterocycles have been discussed in this article. The state of art, challenges, and future perspective have been highlighted in the present collection.



Publication History

Received: 30 May 2025

Accepted after revision: 17 September 2025

Accepted Manuscript online:
17 September 2025

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