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DOI: 10.1055/a-2701-6151
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New Advances in Atroposelective Synthesis of Axial Chirality via Asymmetric Gold(I)-Catalyzed Annulation of Diazo-Alkynes

Yi-Bo Wang
1   College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, China (Ringgold ID: RIN26495)
,
Xin Nie
2   College of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing, China (Ringgold ID: RIN372299)
,
Long Li 
3   College of Chemistry &Materials Engineering, Wenzhou University, Wenzhou, China (Ringgold ID: RIN26495)
› Author Affiliations
Supported by: Zhejiang Provincial Natural Science Foundation of China LQ23B020002
Supported by: National Natural Science Foundation of China 22401218
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Atropisomeric architectures, now as a characteristic of valuable chiral ligands and organocatalysts, are increasingly encountered in modern materials and pharmacy. More importantly, the Au-catalyzed diazo-alkyne carbocyclization has become a flexible tool for facile construction of carbocyclic compounds, yet the preparation of axial chirality via asymmetric gold-catalyzed intermolecular alkyne transformations is scarcely reported. This mini-review aims to summarize the latest development of the axial atroposelective synthesis via Au-catalyzed annulation of diazo-alkyne.



Publication History

Received: 17 July 2025

Accepted after revision: 14 September 2025

Accepted Manuscript online:
14 September 2025

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