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Synthesis
DOI: 10.1055/a-2641-8389
DOI: 10.1055/a-2641-8389
paper
Green Light-Driven Reduction of Methylenemalononitriles with Formate as a Reductant Without a Thiol Hydrogen-Atom-Transfer Catalyst
This work is supported by the National Natural Science Foundation of China (8217131836).
Abstract
The reduction of methylenemalononitriles to their corresponding methylmalononitriles represents an important transformation in organic synthesis, owing to the ready availability of these starting materials. Herein, we report a safe, cost-effective, and practical photochemical reduction employing readily accessible organophotocatalyst and formate without thiol-mediated HAT catalysts. This method accommodates a broad substrate scope, including diverse (hetero)aryl-substituted methylenemalononitriles, delivering moderate to excellent yields.
Publikationsverlauf
Eingereicht: 24. April 2025
Angenommen nach Revision: 23. Juni 2025
Accepted Manuscript online:
23. Juni 2025
Artikel online veröffentlicht:
31. Juli 2025
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