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Synthesis
DOI: 10.1055/a-2311-3930
paper

Pd-catalyzed regioselective tandem C-S/C-N bond formation for modular synthesis of pyrimidine-fused benzothiazoles from o-dihaloarenes and 3,4-dihydropyrimidin-2-thiones

xuying hu
1   School of Chemistry, Chemical Engineering and Resource Utilisation, Northeast Forestry University, Harbin, China (Ringgold ID: RIN47820)
,
ruiqi Liu
2   School of Chemistry, Chemical Engineering and Resource Utilisation, Northeast Forestry University, Harbin, China (Ringgold ID: RIN47820)
,
shiwen Fu
3   School of Chemistry, Chemical Engineering and Resource Utilisation, Northeast Forestry University, Harbin, China (Ringgold ID: RIN47820)
,
Lianxu Shi
4   School of Chemistry, Chemical Engineering and Resource Utilisation, Northeast Forestry University, Harbin, China (Ringgold ID: RIN47820)
,
Chunxia Chen
5   College of Science, Northeast Forestry University, Department of Chemistry and Chemical Engineering, Harbin, China
,
Jinsong Peng 
6   College of Science, Northeast Forestry University, Department of Chemistry and Chemical Engineering, Harbin, China
› Author AffiliationsSupported by: the Natural Science Foundation of Heilongjiang Province LH2022B003,ZD2021C001
Supported by: the National Natural Science Foundation of China 32370413
Supported by: the Fundamental Research Funds for the Central Universities 2572023CT12
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A Pd-catalyzed annulation reaction for the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives via regioselective tandem C-S/C-N bond formation was developed. With PdCl2(PPh3)2 as the precatalyst, Davephos as the ligand, and K2CO3 as the base, various 3,4-dihydropyrimidin-2-thiones with o-dihaloarenes proceeded smoothly, and the desired products were obtained in moderate to good yields



Publication History

Received: 21 February 2024

Accepted after revision: 22 April 2024

Accepted Manuscript online:
22 April 2024

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