Metal-Free Synthesis of 9-Sulfenylphenanthrenes via HNO₃/HCl-Promoted Annulation of 2-Alkynylbiaryls with Disulfides

Abstract

A metal-free thiolative annulation of 2-alkynylbiaryls with disulfides has been developed. This mild and efficient approach was promoted by inexpensive HNO₃/HCl and afforded a range of corresponding 9-sulfenylphenanthrenes in good to excellent yields with a broad substrate scope and high functional group tolerance. Both sulfide groups of the disulfide reagent were used in the reaction.

Key words

metal-free - thiolative - annulation - disulfides - alkynylbiaryls - sulfenylphenanthrenes

Publication History

Received: 26 September 2023

Accepted after revision: 06 November 2023

Accepted Manuscript online:
06 November 2023

Article published online:
11 December 2023

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