DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 21 · July 2025 DOI: 10.1055/s-015-61855

Synthesis of Natural Products

z659
All PDFs of this category
659
Total Synthesis of (+)-Nimbolide
660
Total Synthesis of (–)-Calidoustene
661
Total Synthesis of (–)-Bisdehydrostemoninine
662
Enantioselective Total Synthesis of (–)-Aspidospermidine and (–)-Limaspermidine
663
Total Synthesis of (–)-10-Demethoxyvincorine
664
Total Synthesis of (±)-Melohemsine K
665
Total Synthesis of (–)-Colombiasin A

Synthesis of Heterocycles

z667
All PDFs of this category
667
Cleavage of Olefins Forming Carbon–Nitrogen Bonds
668
A Mild Methodology for the Synthesis of Pyrroline Derivatives
669
Sustainable Photoinduced Difunctionalization of Olefins
670
Modular Access to Thiazoles Using Bromoisocyanoalkenes
671
Catalyst-Controlled Cycloaddition for the Synthesis of Bridged Sulfur Heterocycles
672
A Multicomponent Reaction to Access Functionalized Azetidine Derivatives
673
One-Pot, Multistep Synthesis of Pyrano[3,2‑b]indol-2-ones
674
Allenyl Sulfones as Substrates in [4+2] Annulation to Access Thiochroman-4-ols
675
Visible-Light-Induced Radical Pyridine Rearrangements via Triplet Energy Transfer
676
Photocatalytic Rearrangement and Cyclization of Boronic Esters

Synthesis of Materials and Unnatural Products

z677
All PDFs of this category
677
Spiro sp3 Carbon Center Formation in One Step
678
Strained Spirocyclobutane from Cross-[2+2]-Cycloaddition in Molecular Cages
679
Nitrogen Insertion into Carbon–Carbon Double Bonds
680
BN-Embedded Terrylene Diimides
681
Ultra-Long Thienoacenes
682
Maleimide-Fused Polyacetylene
683
From Cycloheptatriene to Conjugated Z,Z,Z-Trienes
684
Cross-Conjugated Polyenes from 2,3-Addition of [3]Cumulene
685
Stereocontrolled Poly(vinyl alcohol) from Tailored Vinylboron
686
Redox-Stable Cyclic Tetraborane

Metals in Synthesis

z687
All PDFs of this category
687
Bench-Stable Bicyclo[1.1.1]pentane Precursors for Photoredox Radical Coupling
688
Synthesis of Primary Arylamines by Electrochemical Nickel-Catalyzed Amination of Aryl Halides with NH3
689
Iminothiolation of Alkenes by Metal-Free Photocatalytic Energy Transfer
690
Iridium-Catalyzed Hydroalkenylation of Alkenes to Access γ-Substituted Chiral Acrylamides
691
Metal-Free Photoredox-Catalyzed Radical Amination of Alkyl Boronates
692
Copper-Catalyzed Asymmetric Hydroboration and Ring-Opening Dihydroboration of Arylidenecyclobutanes
693
Dual Photocatalysis for Remote C(sp3)–H Acylation
694
Titanium-Catalyzed Radical Kinetic Resolution of Aziridines Using Water as Hydrogen Atom Donor
695
Regioselective Synthesis of Eight-Membered Benzosilacycles via Ring Expansion of Silacyclobutanes
696
Electrochemical Nickel-Catalyzed Enantioconvergent Vinylogous Radical Additions to Silyl Polyenolates
697
A Shocking Advance in Palladium-Catalyzed Carbonylation
698
Ruthenium-Catalyzed Regiodivergent Methylsilylation via C(sp2)–H Activation
699
Photoinduced Nickel-Catalyzed 1,2-Acylcyanation of Styrenes with Acyl Fluorides and Trimethylsilyl Cyanide
700
Directing-Group-Enabled Palladium-Catalyzed Reverse Regioselective Dicarbofunctionalization of Acrylamides
701
Copper-Catalyzed Asymmetric Rearrangement of Carbonyl-Substituted Cyclopropanes to Dihydrofurans
702
Accessing Cyclopropenes and Oxazoles from α-Diazoesters under Cobalt Metalloradical Catalysis
703
Iridium-Catalyzed Intramolecular Alkene–Alkyne Cross-Coupling to Access Macrocyclic 1,3-Dienes
704
Photochemical Transfer of C(sp2)–I Bonds to C(sp3)–I Bonds via a Palladium-Catalyzed HAT Reaction
705
Nickel-Catalyzed Cross-Coupling of Carbonyls and Allylic Alcohols through a Hydrazone Intermediate
706
Accessing Dihydropyrans Under Palladium/Chiral Phosphonic Acid Synergistic Catalysis
707
Regioselective Hydroarylation of gem-Difluoroalkenes under Nickel Hydride Catalysis
708
Palladium-Catalyzed Formation of Phosphine Oxides Tethered to Tetrasubstituted Allenones
709
Palladium-Catalyzed Synthesis of 2,3-Dialkylindoles from ortho-Alkenylisocyanobenzenes
710
Donor/Donor Rhodium Carbenes as Isobenzofuran Precursors
711
Iridium-Catalyzed Enantioselective Hydrogenation of 1,2-Azaborines
712
Tin-Free Palladium-Catalyzed Coupling of Secondary Amines with Aryl Bromides

Polymer-Supported Synthesis

z713
All PDFs of this category
713
Helically Chiral Polyquinoxaline Carboxylates Bearing Achiral Ar3P for Asymmetric Suzuki Coupling in Water
714
Magnetite-Catalyzed Cross-Dehydrogenative Coupling of Aldehydes and Thiols Forming Thioesters
715
Regioselective Synthesis of Indenones Using Phosphine-Based Porous-Polymer-Supported Pd Nanoparticles
716
Synthesis of Pyrrolo[1,2-a]quinoxalines through a Three-Component Reaction with Fe-Ru on γ-Al2O3
717
A Mn-salen Complex Supported on Carbon Nitride for Photoinduced Difunctionalization of Terminal Alkenes
718
Reductive N-Formylation of Amines Using an Ionic Polymer under Carbon Dioxide
719
A MOF Catalyst for Carboxylation of Terminal Epoxides and Oxidative Carboxylation of Styrenes
720
Knoevenagel and Claisen–Schmidt Condensations in Water Using NHSO3H-Functionalized Natural Asphalt
721
Photo-Induced Hydroxytrifluoromethylation Catalyzed by Micelles of a Metal Complex Surfactant
722
Aerobic Oxidation of Benzyl Alcohols Using SO42– and a Nitrogen-Containing TiO2 Photocatalyst

Organo- and Biocatalysis

z723
All PDFs of this category
723
Enantioselective Radical Acyl-Trifluoromethylation of Olefins
724
Organocatalytic Enantioselective Access to Phosphorus(V) Stereocenters
725
Photoredox- and Enzyme-Catalysis Enables Enantioselective Anti-Markovnikov Hydroarylations of Olefins
726
Stereoselective Access to Noradamantane Derivatives
727
Asymmetric Counteranion Directed Photoredox Catalysis (ACPC)-Enabled Deracemization of Ketones
728
Synthesis of Boryl 1,4-Dicarbonyl Compounds via Dual Photoredox-NHC Catalysis
729
Chiral Brønsted Base Catalyzed (3+2) Annulation of Cyclopropanes with Nitrosoarenes
730
(Photo)Biocatalytic Approach towards Radical Cross-Coupling Mediated by Thiamine Acting as NHC
731
Photocatalyst-Dependent Deracemization of Cyclic α-Aryl Ketones via ACPC
732
Enantioselective Photochemical Generation of a cis-Cycloheptenone Isomer
733
In Situ Generated Phenothiazine Sulfoxide Enables Reductive γ-Lactone Synthesis via Peroxide Activation

Innovative Drug Discovery and Development

z735
All PDFs of this category
735
Scaling Complexity: A Streamlined Route to the Northern Fragment of Enlicitide
736
Synthesis of a Cross-Linked Macrocyclic PCSK9 Inhibitor
737
Dispersion Enables Asymmetric Amination of Near-Symmetric Carbon Radicals
738
Large-Scale Synthesis of Rawal’s Diene
739
Dropping Acid without the Trip
740
Unexpected Isoxazole Recombination Photochemistry Unlocks Novel Bioorthogonal Pyrrole Synthesis
741
Stereodivergent Synthesis of Cyanocyclopropanes via Asymmetric Nitrogen Insertion
742
Novel Mitsunobu Reagent Enables Stereospecific Substitution of Alcohols with Amines
743
Iron-Catalyzed Radical Hydroamidation of Alkenes and Further Cyanamide Transformations
744
Evading E3 Ligase Necessity in PROTACs via the ByeTAC

Peptide Chemistry

z745
All PDFs of this category
745
Site-Selective Late-Stage Chlorination of Peptides
746
One-Pot Peptide Synthesis under Neutral Conditions Using Triphenyl Phosphite
747
Spirocyclization of γ-C(sp3)–H Activated Substituted Amino Acids with Maleimides by Palladium Catalysis
748
Enantioselective Synthesis of Fluorinated Quaternary α‐Amino Acids via Desulfonylative SN2′ Substitution
749
Synthesis of Amino Acids via Oxidative N-Dealkylation of Cyclic Amines Utilizing a Manganese Catalyst
750
Photoredox-Catalyzed Synthesis of Unnatural Amino Acids
751
Racemization- and Epimerization-Free Stereoselective Synthesis of (Z)-Fluoroalkene-Type Peptidomimetics
752
Synthesis of Fluorinated Analogues of Amino Acids
753
β-Amino Acid Synthesis from Alkylamine and Silylated Alkenes
754
Cycloaddition of α-Amino Acid Schiff Bases for the Synthesis of α-Tetrasubstituted Pyrrolidine Derivatives
755
Synthesis of Hydroxymates of α-Amino Acids

Flow Chemistry

z757
All PDFs of this category
757
In-Flow Oxidation of Primary Alcohols to Carboxylic Acids Using H2O2 and a Pt/SiO2 Catalyst
758
Synthesis of Alkyl Azetidines via Batch and Flow Photochemistry