Spiro sp3 Carbon Center Formation in One Step

Dahui Zhao; Haochen Li

doi:10.1055/a-2601-4409

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Synfacts 2025; 21(07): 677
DOI: 10.1055/a-2601-4409

Synthesis of Materials and Unnatural Products

Spiro sp³ Carbon Center Formation in One Step

Contributor(s):

Dahui Zhao

,

Haochen Li

Sun Q, Belting J-N, Hauda J, Tymann D, Antoni PW, Goddard R, Hansmann MM *. Technische Universität Dortmund, Germany
Spiro-C(sp³)-Atom Transfer: Creating Rigid Three-Dimensional Structures with Ph₂SCN₂ .

Science 2025;
387: 885-892
DOI: 10.1126/science.ads5974

Crossref PubMed Search in Google Scholar

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Abstract
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Keywords

spiro structures - one-pot reaction - metal-free synthesis - diazosulfur ylides

Significance

A powerful reagent, diazosulfur ylide (Ph₂SCN₂), is developed, demonstrating the reactivity of sulfur ylide and diazo- compounds, and enables highly efficient formation of various C(sp³)-centered spiro-molecules.

Comment

The method allows for the construction of four new C–C or C–N/O bonds surrounding a C(sp³) center in one step, without using any transition-metal catalyst or reagent.

Publication History

Article published online:
23 June 2025

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

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