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DOI: 10.1055/a-2601-4864
Bench-Stable Bicyclo[1.1.1]pentane Precursors for Photoredox Radical Coupling
Rapid Access to 3-Substituted Bicyclo[1.1.1]pentanes.
Chem 2025;
11: 102537
DOI: 10.1016/j.chempr.2025.102537

Significance
The authors utilized N-hydroxyphthalimide (NHPI)-functionalized bicyclo[1.1.1]pentanes (BCPs) as radical coupling partners. An in situ generated silyl radical acted as the key halogen atom transfer (XAT) reagent to produce alkyl or aryl radicals from alkyl or aryl bromides.
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Comment
This methodology was carried out successfully on analogues containing drug-relevant structural motifs, showcasing potential application in a pharmaceutical setting. Aryl, heteroaryl, primary, secondary, and tertiary alkyl coupling partners were all tolerated, highlighting the broad functional group tolerance of this method.
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Publikationsverlauf
Artikel online veröffentlicht:
23. Juni 2025
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