DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 19 · September 2023 DOI: 10.1055/s-013-58080

Synform

A149
Zanda, Matteo: SYNFORM ISSUE 2023/09

Synthesis of Natural Products

z0849
All PDFs of this category
0849
Total Synthesis of (–)-Mitragynine Pseudoindoxyl
0850
Synthesis of (–)-Caulamidine A
0851
Synthesis of (+)-Malettinin C and (+)-Malettinin E
0852
Total Synthesis of (–)-Retigeranic Acid A
0853
Synthesis of (+)-Hinckdentine A
0854
Synthesis of (+)-Asteriscanolide

Synthesis of Heterocycles

z0855
All PDFs of this category
0855
Rh-Catalyzed Asymmetric Carbometallation to Access 3-Substituted Piperidines
0856
Synthesis of Hybrid Scaffolds Featuring 4-Pyridine and 4-Piperidine Moieties
0857
Cu-Mediated C(sp2)–H Elaboration of Benzylic Scaffolds
0858
Copper-Catalyzed Synthesis of Axially Chiral Arylpyrroles via Atroposelective Cyclization of Diyne
0859
One-Pot Synthesis of Pyrazolooxazines from 2,2-Dichlorovinylacetophenones
0860
Efficient Exploration of Reaction Space to Optimize Sustainable Cu-Mediated Ullmann Couplings
0861
Photocatalyzed Formate-Mediated Deoxygenation of Alcohols through Benzoate Ester Intermediates
0862
Synthesis of Polysubstituted Furans via Electrocatalyzed Cyclization
0863
Synthesis of Azabicyclic Systems through [3+2] Cycloaddition of Oxidopyridinium Ions
0864
Versatile Synthesis of 4-Fluoropyrroles
0865
Regioselective Synthesis of Isoxazoles from Ynones
0866
Catalyst-Controlled [3+2] Cycloaddition for the Synthesis of endo- or exo-Substituted Pyrrolidines
0867
Catalytic Asymmetric Synthesis of Morpholinones and Piperazinones via Domino Ring-Opening Cyclization

Synthesis of Materials and Unnatural Products

z0869
All PDFs of this category
0869
Adamantane-Annulated Arenes
0870
Synthesis of Boratatriptycene
0871
Molecular Cage from Diradical Dimerization
0872
A New Benzotrisazulene Synthesis
0873
Arylquinoline from Three Components in One-Pot
0874
One Stone, Two Birds: Versatile Grignard Reagent-Enabled Coupling for Advanced Arylamines and Biaryls
0875
Aromatic C–C Bond Cleavage in a Curved π‑System of Aminocorannulene
0876
A Helicene-Bridged Cyclophane
0877
Synthesis of Tetraphenanthroporphyrins
0878
A Self-Accelerated Polymerization
0879
Tetraradical in Cyclic Paraphenylene
0880
Facile 10- and 11-Membered Azalactam Synthesis

Metals in Synthesis

z0881
All PDFs of this category
0881
Making Acid Chlorides from Olefins by Palladium-Catalyzed Regiodivergent Hydrochlorocarbonylation
0882
Palladium-Catalyzed Synthesis of Polysubstituted Cyclopropanecarbonitriles
0883
Rhodium Catalyzed Aryl C–H Functionalization with Nitroalkenes
0884
Nickel-Catalyzed Alkenyl C(sp2)–H Functionalization via an Aryl-to-Vinyl 1,4-Nickel/Hydride Shift
0885
Rh-Catalyzed Synthesis of Propargylic Sulfides via a [2,3]-Sigmatropic Rearrangement
0886
Synthesis of Chiral meta-Arylated 2-Aryl Anilines via an Atroposelective Palladation Relay
0887
Copper-Catalyzed Three-Component Carboesterification of Styrenes to Access Chiral γ-Butyrolactones
0888
C(sp3)–H Functionalization Enabled by Hydrogen Atom Transfer with Tertiary Cyclopropyl Radicals
0889
Palladium-Catalyzed Cross-Coupling of 2-Benzoylpyridine N-Oxides via C(sp2)–C(O) Bond Cleavage
0890
Synergystic Catalysis Used Toward the Synthesis of Strychnan Alkaloids
0891
Enantioselective Hydroamination of Cyclopropenes Catalyzed by Copper
0892
Synthesis of β-N-Glycopyranosides via Palladium-Catalyzed Tsuji–Trost Amination
0893
Synthesis of Imidazolidines by Copper-Catalyzed Formal (3+2) Cycloaddition of Aziridines and Diazetidines
0894
Cyclization of Enynes by Iron-Catalyzed Hydrochlorination
0895
Nickel-Catalyzed Synthesis of Hydrazides from O-Benzoylated Hydroxamates and Aryl/Aliphatic Amines
0896
Nickel-Catalyzed Regioselective Allylic Alkylation of Unsymmetric Ketones at the Higher-Substituted α-Site
0897
Palladium-Catalyzed Directed Regio- and Stereoselective 1,1-Diarylation of Alkenes
0898
Dual Nickel/Photoredox-Catalyzed Regioselective β-Allylation of Silyl Enol Ethers
0899
Regio- and Chemoselective Synthesis of Trisubstituted Allenes via a Pd-Catalyzed Three-Component Reaction
0900
Chromium-Catalyzed Enantioselective Cyclopropanation of Terminal Olefins with gem-Dihaloalkanes
0901
Aerobic α,β-Dehydrogenation of Lactams and Flavanones under Iron Catalysis
0902
Rh-Catalyzed Regio- and Diastereoselective Synthesis of Difluorinated Cyclopentanes via a [3+2] Cycloaddition
0903
Time-Dependent Synthesis of Spirocyclic Silacycles via Pd-Catalyzed Domino C–H Activation Reactions
0904
Ru-Catalyzed Intermolecular [4+3] Cycloaddition of ortho-Quinone Methides with Carbonyl Ylides
0905
The Overman Asymmetric Intramolecular Heck Reaction for the Synthesis of 3-Alkyl-3-Aryloxindoles
0906
Asymmetric Alkylation of N‑Sulfonyl Ketimines
0907
The Larock Indole Synthesis: Pd-Catalyzed Annulation of 2-Iodoaniline and Internal Alkyne Derivatives

Polymer-Supported Synthesis

z0909
All PDFs of this category
0909
Electrochemical Allylation of Imines Promoted by Single-Atomic Zinc on Nitrogen-Doped Carbon
0910
Selective Oxidation of Sulfides to Sulfoxides by a Nickel-Salphen Based Porous Organic Polymer Catalyst
0911
Photocatalytic α-Alkynylation of Tertiary Amines by Copper-Doped Carbon Nitride
0912
Photocatalytic Oxidative Hydroxylation of Arylboronic Acids to Phenols by a CdS-TiO2 Nanohybrid
0913
Photocatalytic Borylation, Silylation, Phosphorylation, and Thiolation Using a Metal–Organic Framework
0914
Photocatalytic Olefination of Aldehydes with Benzyl Bromides Promoted by Quantum Dots
0915
A Polyacrylonitrile Fiber-Supported Acid-Base Bifunctional Catalyst for the Henry Reaction
0916
One-Pot Four-Component Synthesis of Substituted Imidazole Derivatives Using Magnetic Polyborate NPs
0917
Photocatalytic C–N Bond Formation with Single Iron Atoms on Sulfur-Containing Carbon Nitride
0918
Visible-Light-Induced Aerobic C=C Bond Cleavage of Vinylarenes Using CsPbBr3

Organo- and Biocatalysis

z0919
All PDFs of this category
0919
Photo-Organocatalyst Enables Reduction of C–F, C–Cl, and C–O Bonds
0920
Asymmetric Dearomatization of N-Heteroarenes Catalyzed by a Multidentate Halogen-Bond Donor
0921
Photocatalytic Radical Alkene Hydrogenation by Phosphine-Mediated Water Activation
0922
NHC Catalysis Permits Regioselective C3–OH or C5–OH Acylation of Unprotected Nucleosides
0923
Discovery of a General Catalyst for the Oxidative Desymmetrization of Structurally Diverse Diols
0924
N-Triflyl Phosphoramide-Catalyzed Atroposelective C–C Cross-Coupling of 1-Azonaphthalenes
0925
Chiral Phosphoric Acid-Catalyzed Asymmetric Synthesis of Remotely Chiral Naphthols and Naphthylamines
0926
Transition-Metal-Free Synthesis of Bicyclo[2.1.1]hexan-2-ones – meta- and ortho-Benzene Bioisosteres
0927
P(III)/P(V) Redox Catalysis Enables Isodesmic Deoxygenation of Phosphine Oxides

Innovative Drug Discovery and Development

z0929
All PDFs of this category
0929
Discovery of Selective SYK Inhibitors by the Macrocyclization and Prodrug Approaches
0930
pH-Switchable Phase-Transfer Agents for Impurity Purging from Biocatalytic Transformations
0931
Bioinspired Total Synthesis and Bioactivity Evaluation of a Novel Sesquiterpene (–)-Adenophorone
0932
Lewis Acid-Mediated Tagging of Bioactive Amides
0933
Site-Specific Functionalization of RNA by a Ribozyme
0934
Discovery of a Potent and Orally Bioavailable Keap1–Nrf2 PPI Inhibitor
0935
The Influence of Variable Solvent Peroxide Levels on endo/exo-Selectivity
0936
Modular Synthesis of Ligand-Directed Covalent Probes
0937
Radio-Pharmaceutical Probe for ROS Self-Monitoring
0938
New sp3-Rich Isosteres of the Phenyl Ring with Enhanced Physicochemical Properties
0939
From Carboxylic Acid Derivatives to Ketones: Modular Ketone Synthesis via Catalytic Olefination
0940
ortho-Substituted Cannabinoids Achieve Axial Chirality and Impact Receptors Affinity
0941
SARS-CoV-2 Inhibitors from Synthetic Alotaketal C Analogs

Peptide Chemistry

z0943
All PDFs of this category
0943
Peptide Elongation Using α-NCAs Both as Nucleophiles and Electrophiles
0944
Cu-Catalyzed Late-Stage Functionalization of Glycine Derivatives and Glycine-Containing Peptides
0945
Silver-Catalyzed Intermolecular [3+2] Cycloaddition for the Synthesis of Tetrazole-Fused Amino Acids
0946
Pinnick Oxidation to Form 4-Substituted Proline
0947
Amine Installation and Facilitated Peptide Elongation
0948
Ir-Catalyzed Functionalization of Cysteine-Containing Peptides
0949
Peptide Modification Using Ag-Catalyzed C–H Amination
0950
Fluorous Sulfur-Containing Boronic Acid Catalyst for Amidation
0951
Synthesis of Sterically Hindered Tripeptides Using a Modified Ugi Reaction
0952
Cu-Catalyzed γ-Addition to Form Unnatural Amino Acid Bearing Allene Units

Flow Chemistry

z0953
All PDFs of this category
0953
Rapid Access to Benzodiazepines Using Flow Chemistry
0954
Transformation of Amides to Nitriles Catalyzed by CeO2 in Continuous-Flow Synthesis