Appl Clin Inform 2014; 05(02): 548-556
DOI: 10.4338/ACI-2014-04-RA-0033
Research Article – ehealth2014 special topic
Schattauer GmbH

A toolbox to improve algorithms for insulin-dosing decision support

K. Donsa
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
,
P. Beck
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
,
J. Plank
2  Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
,
L. Schaupp
2  Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
,
J. K. Mader
2  Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
,
T. Truskaller
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
,
B. Tschapeller
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
,
B. Höll
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
,
S. Spat
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
,
T. R. Pieber
1  HEALTH – Institute for Biomedicine and Health Sciences, JOANNEUM RESEARCH Forschungsgesellschaft mbH, Graz, Austria
2  Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria
› Author Affiliations
Further Information

Correspondence to:

Peter Beck, PhD
JOANNEUM RESEARCH-HEALTH
Elisabethstraße 5
8010 Graz
Austria

Publication History

Received: 03 April 2014

Accepted: 30 April 2014

Publication Date:
21 December 2017 (online)

 

Summary

Background: Standardized insulin order sets for subcutaneous basal-bolus insulin therapy are recommended by clinical guidelines for the inpatient management of diabetes. The algorithm based GlucoTab system electronically assists health care personnel by supporting clinical workflow and providing insulin-dose suggestions.

Objective: To develop a toolbox for improving clinical decision-support algorithms.

Methods: The toolbox has three main components. 1) Data preparation: Data from several heterogeneous sources is extracted, cleaned and stored in a uniform data format. 2) Simulation: The effects of algorithm modifications are estimated by simulating treatment workflows based on real data from clinical trials. 3) Analysis: Algorithm performance is measured, analyzed and simulated by using data from three clinical trials with a total of 166 patients.

Results: Use of the toolbox led to algorithm improvements as well as the detection of potential individualized subgroup-specific algorithms.

Conclusion: These results are a first step towards individualized algorithm modifications for specific patient subgroups.

Citation: Donsa K, Beck P, Plank J, Schaupp L, Mader JK, Truskaller T, Tschapeller B, Höll B, Spat S, Pieber TR. A toolbox to improve algorithms for insulin-dosing decision support. Appl Clin Inf 2014; 5: 548–556 http://dx.doi.org/10.4338/ACI-04-RA-0033


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Conflict of interest

The authors declare that they have no conflicts of interest in the research.


Correspondence to:

Peter Beck, PhD
JOANNEUM RESEARCH-HEALTH
Elisabethstraße 5
8010 Graz
Austria