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Synthesis 2008(1): 127-135  
DOI: 10.1055/s-2007-990905
PAPER
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Double Suzuki-Miyaura Cross-Coupling in the 6,8-Dibromoimidazo[1,2-a]pyridine Series

Rémi Szabo, Maxime D. Crozet, Patrice Vanelle*
Laboratoire de Chimie Organique Pharmaceutique, LCOP-UMR CNRS 6517, Faculté de Pharmacie, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Fax: +33(4)91794677; e-Mail: patrice.vanelle@pharmacie.univ-mrs.fr;
Further Information

Publication History

Received 21 September 2007
Publication Date:
15 November 2007 (online)

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Abstract

New, potentially bioactive, imidazopyridine derivatives were synthesized in a highly efficient synthesis in four steps from 2-amino-3,5-dibromopyridine using microwave-assisted double Suzuki-Miyaura cross-coupling methodology.

Key words

double cross-coupling - microwaves - imidazo[1,2-a]pyridine - sulfones - spectroscopy

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Detailed X-ray crystallographic data are available from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2, 1EZ, UK (for compound 4, CCDC 659668; 5, CCDC 659669; 6, CCDC 659670). These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.