Abstract
Backround: Preoperative anemia has been shown to be an ominous prognostic factor for survival
in patients with early stage non small cell lung cancer. Methods: Two hundred and fourteen patients underwent resection for early stage non small cell
lung cancer between 2001 and 2006 without neo-adjuvant treatment. Patients were divided
into four groups based on their admission hemoglobin (Hgb): group I: Hgb ≤ 12 g/dl,
group II: Hgb = 12.1 - 12.9 g/dl, group III: Hgb = 13.0 - 14.0 g/dl, and group IV:
Hgb > 14 g/dl. Cox regression analysis was used to evaluate each variable's impact
on midterm survival taking all causes and lung cancer-specific mortality into account.
Kaplan-Meier survival plots were estimated. Results: Preoperative hemoglobin (HR = 1.44, 95 % confidence intervals 1.08 - 1.94, p = 0.014) and pneumonectomy (HR = 3.58, 95 % confidence intervals 1.26 - 10.16, p = 0.017) were the only predictors of all-cause midterm mortality. Similarly, when
only lung cancer-related mortality was considered, preoperative hemoglobin (HR = 1.81,
95 % confidence intervals 1.17 - 2.78, p = 0.007) and pneumonectomy (HR = 6.89, 95 % confidence intervals 2.29 - 20.73, p = 0.001,) were independent predictors. Age, gender, pulmonary function test results,
tumor stage, and histology did not influence survival. Conclusions: Preoperative anemia and the type of resection in early stage non small cell lung
cancer have an impact on midterm survival and lung cancer-specific mortality.
Key words
anemia - non small cell lung cancer - neo‐adjuvant treatment - survival
References
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