Novel Synthesis of Arylethynyl Heterocycles

Roger Soley; Fernando Albericio; Mercedes Álvarez

doi:10.1055/s-2007-966041

PAPER

Novel Synthesis of Arylethynyl Heterocycles

Roger Soley^a, Fernando Albericio^a,b, Mercedes Álvarez*^a,c
^a Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, 08028 Barcelona, Spain
^b Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain
^c Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain
e-Mail: malvarez@pcb.ub.es;

Abstract

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Abstract

A new and simple synthesis of 2-arylethynylindole and 2-arylethynylpyrrole is described. N-Deprotection and subsequent base-catalyzed elimination of N-tosylheteroaryl benzyl ketones are the key steps of the process.

Key words

acetylenes - indole - pyrrole - elimination - tosyl protecting group

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References

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