A Facile Synthesis of Oxazolines, Thiazolines, and Imidazolines Using α,α-Difluoroalkylamines

Tsuyoshi Fukuhara; Chihiro Hasegawa; Shoji Hara

doi:10.1055/s-2007-966038

PAPER

A Facile Synthesis of Oxazolines, Thiazolines, and Imidazolines Using α,α-Difluoroalkylamines

Tsuyoshi Fukuhara, Chihiro Hasegawa, Shoji Hara*
Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan
Fax: +81(11)7066556; e-Mail: shara@eng.hokudai.ac.jp;

Abstract

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Abstract

β-Amino alcohols, β-amino thiols, and β-diamines can be converted to the corresponding oxazoline, thiazoline, and imidazoline derivatives, respectively, by reaction with α,α-difluoroalkylamines under mild conditions. The reaction is applicable for the synthesis of optically active heterocyclic compounds.

Key words

α,α-difluoroalkylamine - heterocycle - amino alcohol - oxazoline - thiazoline - imidazoline

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References

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