Synthesis 2006(19): 3157-3188  
DOI: 10.1055/s-2006-950202
REVIEW
© Georg Thieme Verlag Stuttgart · New York

Synthetic Strategies towards Naturally Occurring Tetronic Acids

Alexandros L. Zografos, Dimitris Georgiadis*
Department of Chemistry, Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Fax: +30(210)7274498; e-Mail: dgeorgia@chem.uoa.gr;
Further Information

Publication History

Received 26 April 2006
Publication Date:
21 August 2006 (online)

Abstract

Many natural products are characterized by the existence of a five-membered vinylogous acid ring, named tetronic acid, in their structure. The intense synthetic interest on such compounds has led to the development of several innovative methodologies for the construction of tetronic subunits, as well as to inspired strategies towards the total synthesis of the compounds themselves. The synthetic progress on the field of naturally occurring tetronic acids is reviewed herein.

  • 1 Introduction

  • 2 5-Ylidene Tetronic Natural Products

  • 3 5-Monosubstituted Tetronic Natural Products

  • 4 5,5-Disubstituted Tetronic Natural Products

  • 5 5-Unsubstituted Tetronic Natural Products

  • 6 Conclusions