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DOI: 10.1055/s-2006-941755
© Georg Thieme Verlag Stuttgart · New York
Tiotropium
TiotropiumPublication History
eingereicht: 31.8.2005
akzeptiert: 12.1.2006
Publication Date:
23 May 2006 (online)

Tiotropiumbromid (Spiriva®) ist ein Parasympatholytikum zur inhalativen Bronchodilatation bei Patienten mit chronisch obstruktiver Lungenerkrankung (COPD). Es unterscheidet sich von den bisher verfügbaren Anticholinergika zur inhalativen Therapie durch seine lang anhaltende Wirkung, die ein entscheidender Vorteil für die langfristige therapeutische Wirksamkeit zu sein scheint, möglicherweise in Wirkqualitäten, die über Bronchodilatation hinausgehen.
Literatur
- 1
Disse B, Reichl R, Speck G, Traunecker W, Rominger K L, Hammer R.
Ba 679 BR, a novel long-acting anticholinergic bronchodilator.
Life Sci.
1993;
52
537-544
MissingFormLabel
- 2
Racké K, Matthiesen S.
The airway cholinergic system: Physiology and pharmacology.
Pulm Pharmacol Ther.
2004;
17
181-198
MissingFormLabel
- 3
Racké K, Juergens U R, Matthiesen S.
Control by cholinergic mechanism.
Eur J Pharmacol (Special issue on respiratory pharmacology).
2005;
2006:
, epub ahead of print, DOI: 10.1016/j.ejphaar.2005.12.050
MissingFormLabel
- 4
Disse B, Speck G A, Rominger K L, Witek T J, Hammer R.
Tiotropium (SpirivaTM): mechanistical considerations and clinical profile in obstructive
lung disease.
Life Sci.
1999;
64
457-464
MissingFormLabel
- 5
Takahashi T, Belvisi M G, Patel H. et al .
Effect of Ba 679 BR, a novel long-acting anticholinergic agent, on cholinergic neurotransmission
in guinea pig and human airways.
Am J Respir Crit Care Med.
1994;
150
1640-1645
MissingFormLabel
- 6 Spiriva® Fachinformation,. Hrsg. Boehringer Ingelheim und Pfizer
MissingFormLabel
- 7
Türck D, Weber W, Sigmund R. et al .
Pharmacokinetics of intravenous, single-dose tiotropium in subjects with different
degrees of renal impairment.
J Clin Pharmacol.
2004;
44
163-172
MissingFormLabel
- 8
Vincken W, van Noord J A, Greefhorst A P. et al .
Improved health outcomes in patients with COPD during 1 yr’s treatment with tiotropium.
Eur Respir J.
2002;
19
209-216
MissingFormLabel
- 9
Koumis T, Samuel S.
Tiotropium bromide: a new long-acting bronchodilator for the treatment of chronic
obstructive pulmonary disease.
Clin Ther.
2005;
27
377-392
MissingFormLabel
- 10
Olin J L.
Tiotropium: an inhaled anticholinergic for chronic obstructive pulmonary disease.
Am J Health Syst Pharm.
2005;
62
1263-1269
MissingFormLabel
- 11
Kroegel C, Buhl R, Gillissen A, Petro W.
Asthma bronchiale versus chronisch-obstruktive Lungenkrankheit (COPD).
Dtsch Med Wochenschr.
2005;
130
812-818
MissingFormLabel
- 12
Tashkin D, Kesten S.
Long-term treatment benefits with tiotropium in COPD patients with and without short-term
bronchodilator responses.
Chest.
2003;
123
1441-1449
MissingFormLabel
- 13
Gosens R, Nelemans S A, Grootte Bromhaar M M, McKay S, Zaagsma J, Meurs H.
Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth
muscle.
Am J Respir Cell Mol Biol.
2003;
28
257-262
MissingFormLabel
- 14
Gosens R, Bos I S, Zaagsma J, Meurs H.
Protective effects of tiotropium bromide in the progression of airway smooth muscle
remodeling.
Am J Respir Crit Care Med.
2005;
171
1096-1102
MissingFormLabel
- 15
Hasani A, Toms N, Agnew J E, Sarno M, Harrison A J, Dilworth P.
The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients
with COPD.
Chest.
2004;
125
1726-1734
MissingFormLabel
- 16
Littner M R, Ilowite J S, Tashkin D P. et al .
Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable
chronic obstructive pulmonary disease.
Am J Respir Crit Care Med.
2000;
161
1136-1142
MissingFormLabel
Prof. Dr. med. Kurt Racké
Institut für Pharmakologie und Toxikologie, Rheinische Friedrich-Wilhelms-Universität
Bonn
Reuterstraße 2b
53113 Bonn
Email: racke.kurt@uni-bonn.de