Abstract
This article presents studies on the development of cross-coupling reactions of aryl
halides and sulfonates with amines, alkoxides, and various enolates. Emphasis is placed
on the process of developing new catalysts with mechanistic information gained in
the author’s laboratory.
1 Introduction
2 Early Reaction Development
3 New Catalyst Developments
4 Mechanism of the Cross-Coupling Processes
5 Mechanism of Oxidative Addition
6 Reductive Elimination of Amines
7 Stable Palladium Catalysts for Coupling of Primary Amines
8 Guidelines for Catalyst Selection
Key words
cross-coupling - palladium - amination - arylation - mechanism
References and Notes
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