Synlett 2006(8): 1197-1200  
DOI: 10.1055/s-2006-939080
LETTER
© Georg Thieme Verlag Stuttgart · New York

Allenes as Dipolarophiles in the Intramolecular Carbene Cyclization-Cyclo­addition Cascade Reaction

Xingxian Zhang, Rebecca Y. Y. Ko, Shuoliang Li, Ru Miao, Pauline Chiu*
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. of China
Fax: +85228571586; e-Mail: pchiu@hku.hk;
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Publikationsverlauf

Received 5 December 2005
Publikationsdatum:
05. Mai 2006 (online)

Abstract

Intramolecular carbene cyclization-cycloaddition cascade reactions with allenes occur efficiently in the presence of dirhodium catalysts to afford oxatricyclic products as single dia­stereomers.

1

Present address: Xingxian Zhang, College of Pharmaceutical Science, Zhejiang University, P. R. of China.